Histamine Intolerance Symptoms: Causes, Signs, and Management

Histamine intolerance is a condition that affects a growing number of people worldwide. It occurs when the body cannot break down histamine, a chemical produced by the immune system. As a result, excess histamine accumulates in the body, causing a wide range of symptoms that can be confusing and difficult to diagnose. In this article, we'll explore the causes, signs, and management of histamine intolerance symptoms, so you can get the help you need to feel better.

What is Histamine Intolerance?

Histamine intolerance is a condition that occurs when there is an excess of histamine in the body. Histamine is a neurotransmitter and a hormone that is produced by the immune system in response to allergens, injury, or infection. It plays a crucial role in regulating inflammation, immune response, and digestion.

When histamine is released in large amounts, it can cause a variety of symptoms, including headaches, hives, itching, flushing, and gastrointestinal problems. While many people can break down histamine easily, some people lack the necessary enzymes to do so, leading to histamine intolerance.

What Causes Histamine Intolerance Symptoms?

There are several factors that can contribute to histamine intolerance symptoms. Some of the most common causes include:

Genetics: Some people are born with genetic mutations that affect the enzymes responsible for breaking down histamine.

Gastrointestinal Issues: People with gut issues like small intestinal bacterial overgrowth (SIBO), leaky gut, and inflammatory bowel disease (IBD) have an increased risk of histamine intolerance.

Medications: Certain medications like non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics can disrupt the balance of gut bacteria and increase histamine levels.

Age: As we age, our body's ability to produce DAO, the primary enzyme responsible for breaking down histamine, decreases.

Diet: Foods high in histamine or that trigger the release of histamine, such as fermented foods, citrus fruits, and alcohol, can worsen symptoms.

Histamine Intolerance Symptoms

The symptoms of histamine intolerance can vary widely from person to person, making it difficult to diagnose. However, some of the most common symptoms include:

Gut & Digestive Symptoms

• Diarrhea
• Abdominal pain
• Bloating
• Nausea
• Vomiting
• Constipation

Skin Symptoms

• Hives
• Itchy skin
• Flushing
• Eczema
• Psoriasis

Respiratory Symptoms

• Runny nose
• Sneezing
• Shortness of breath
• Wheezing

Cardiac Symptoms

• Rapid heartbeat
• Low blood pressure
• Irregular heartbeat

Circulatory Symptoms

• Dizziness
• Headache
• Fatigue
• Migraines

Psychological Symptoms

• Anxiety
• Depression
• Mood swings
• Brain fog
• Insomnia

Medical Treatments for Histamine Intolerance Symptoms

If you suspect that you have histamine intolerance symptoms, it's essential to talk to your healthcare provider. Your doctor may recommend testing for DAO enzyme levels or food allergies to confirm the diagnosis.

The most effective way to manage histamine intolerance is through dietary changes. A low-histamine diet involves avoiding foods high in histamine, including aged cheese, fermented foods, alcohol, and citrus fruits. Your doctor may also recommend supplements like DAO enzymes, vitamin C, and zinc to help break down histamine.

In some cases, antihistamine medications may be prescribed to help relieve symptoms like itching and hives. However, these medications are not a long-term solution and can have side effects.

Histamine Intolerance Symptoms and Wine

Due to the histamines that occur naturally in grapes, drinking wine can trigger a number histamine symptoms listed above.  Fortunately, PureWine have developed a patented method of removing histamines from wine without changing the taste, color or viscosity of the wine.  Check out our product pages and reviews to learn more about how you can enjoy wine without the side effects and symptoms of histamine intolerance. 


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